Cargando…

DNA methylation of a NF-κB binding site in the aquaporin 5 promoter impacts on mortality in sepsis

Altered aquaporin 5 (AQP5) expression in immune cells impacts on key mechanisms of inflammation and is associated with sepsis survival. Since epigenetic regulation via DNA methylation might contribute to a differential AQP5 expression in sepsis, we tested the hypotheses that DNA methylation of the A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rump, Katharina, Unterberg, Matthias, Dahlke, Agnes, Nowak, Hartmuth, Koos, Björn, Bergmann, Lars, Siffert, Winfried, Schäfer, Simon T., Peters, Jürgen, Adamzik, Michael, Rahmel, Tim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898603/ https://www.ncbi.nlm.nih.gov/pubmed/31811204 http://dx.doi.org/10.1038/s41598-019-55051-8

Ejemplares similares

Major Adverse Kidney Events Are Associated with the Aquaporin 5 -1364A/C Promoter Polymorphism in Sepsis: A Prospective Validation Study
por: Bergmann, Lars, et al.
Publicado: (2020)

The aquaporin 5 -1364A/C promoter polymorphism impacts on resolution of acute kidney injury in pneumonia evoked ARDS
por: Rahmel, Tim, et al.
Publicado: (2018)

The Pro-Inflammatory Deletion Allele of the NF-κB1 Polymorphism Is Characterized by a Depletion of Subunit p50 in Sepsis
por: Marko, Britta, et al.
Publicado: (2022)

The Aquaporin 3 Promoter Polymorphism −1431 A/G is Associated with Acute Graft Rejection and Cytomegalovirus Infection in Kidney Recipients Due to Altered Immune Cell Migration
por: Rump, Katharina, et al.
Publicado: (2020)

The Aquaporin 5 −1364A/C Promoter Polymorphism Is Associated With Cytomegalovirus Infection Risk in Kidney Transplant Recipients
por: Rahmel, Tim, et al.
Publicado: (2019)

Corrigendum: The Aquaporin 5 −1364A/C Promoter Polymorphism Is Associated With Cytomegalovirus Infection Risk in Kidney Transplant Recipients
por: Rahmel, Tim, et al.
Publicado: (2021)

Mitochondrial dysfunction in sepsis is associated with diminished intramitochondrial TFAM despite its increased cellular expression
por: Rahmel, Tim, et al.
Publicado: (2020)

The NFKB1 Promoter Polymorphism (-94ins/delATTG) Is Associated with Susceptibility to Cytomegalovirus Infection after Kidney Transplantation and Should Have Implications on CMV Prophylaxis Regimens
por: Nowak, Hartmuth, et al.
Publicado: (2021)

AQP5-1364A/C polymorphism and the AQP5 expression influence sepsis survival and immune cell migration: a prospective laboratory and patient study
por: Rump, Katharina, et al.
Publicado: (2016)

The Distinctive Activation of Toll-Like Receptor 4 in Human Samples with Sepsis
por: Thon, Patrick, et al.
Publicado: (2022)

Midazolam impacts acetyl—And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium?
por: Rump, Katharina, et al.
Publicado: (2022)

Function of aquaporins in sepsis: a systematic review
por: Rump, Katharina, et al.
Publicado: (2018)

LPS-Induced Endotoxemia Evokes Epigenetic Alterations in Mitochondrial DNA That Impacts Inflammatory Response
por: Koos, Björn, et al.
Publicado: (2020)

Response to comment on human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis
por: Koos, Björn, et al.
Publicado: (2023)

A novel understanding of postoperative complications: In vitro study of the impact of propofol on epigenetic modifications in cholinergic genes
por: Holtkamp, Caroline, et al.
Publicado: (2019)

Long-term mortality and outcome in hospital survivors of septic shock, sepsis, and severe infections: The importance of aftercare
por: Rahmel, Tim, et al.
Publicado: (2020)

Hydrocortisone Fails to Abolish NF-κB1 Protein Nuclear Translocation in Deletion Allele Carriers of the NFKB1 Promoter Polymorphism (-94ins/delATTG) and Is Associated with Increased 30-Day Mortality in Septic Shock
por: Schäfer, Simon T., et al.
Publicado: (2014)

The impact of the COVID-19 pandemic on non-COVID induced sepsis survival
por: Unterberg, Matthias, et al.
Publicado: (2022)

The -1364A/C Aquaporin 5 Gene Promoter Polymorphism Is Not Associated with Menière's Disease
por: Arweiler-Harbeck, Diana, et al.
Publicado: (2012)

AQP5-1364A/C Polymorphism Affects AQP5 Promoter Methylation
por: Rump, Katharina, et al.
Publicado: (2022)

Increased circulating microRNA-122 is associated with mortality and acute liver injury in the acute respiratory distress syndrome
por: Rahmel, Tim, et al.
Publicado: (2018)

Increased circulating microRNA-122 is a biomarker for discrimination and risk stratification in patients defined by sepsis-3 criteria
por: Rahmel, Tim, et al.
Publicado: (2018)

Evaluation of inhaled salbutamol effectiveness under supportive use of electrical impedance tomography in ventilated ICU patients: study protocol for a randomised controlled clinical trial
por: Rahmel, Tim, et al.
Publicado: (2019)

Legionella contamination of a cold-water supplying system in a German university hospital – assessment of the superheat and flush method for disinfection
por: UNTERBERG, MATTHIAS, et al.
Publicado: (2021)

NFKB1 Promoter DNA from nt+402 to nt+99 Is Hypomethylated in Different Human Immune Cells
por: Unterberg, Matthias, et al.
Publicado: (2016)

Decreased protein binding of moxifloxacin in patients with sepsis?
por: Dorn, Christoph, et al.
Publicado: (2017)

Epigenetic Mechanisms of Postoperative Cognitive Impairment Induced by Anesthesia and Neuroinflammation
por: Rump, Katharina, et al.
Publicado: (2022)

Increased prevalence of clonal hematopoiesis of indeterminate potential in hospitalized patients with COVID-19
por: Schenz, Judith, et al.
Publicado: (2022)

Moxifloxacin monotherapy versus combination therapy in patients with severe community-acquired pneumonia evoked ARDS
por: Rahmel, Tim, et al.
Publicado: (2017)

Human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis
por: Unterberg, M., et al.
Publicado: (2023)

Impact of carbohydrate-reduced nutrition in septic patients on ICU: study protocol for a prospective randomised controlled trial
por: Rahmel, Tim, et al.
Publicado: (2020)

Whole blood impedance aggregometry as a biomarker for the diagnosis and prognosis of severe sepsis
por: Adamzik, Michael, et al.
Publicado: (2012)

Therapeutic Suggestions During General Anesthesia Reduce Postoperative Nausea and Vomiting in High-Risk Patients – A Post hoc Analysis of a Randomized Controlled Trial
por: Nowak, Hartmuth, et al.
Publicado: (2022)

Effect of therapeutic suggestions during general anaesthesia on postoperative pain and opioid use: multicentre randomised controlled trial
por: Nowak, Hartmuth, et al.
Publicado: (2020)

Human Norovirus Induces Aquaporin 1 Production by Activating NF-κB Signaling Pathway
por: Zhang, Mudan, et al.
Publicado: (2022)

Free hemoglobin concentration in severe sepsis: methods of measurement and prediction of outcome
por: Adamzik, Michael, et al.
Publicado: (2012)

Hypoxia Inducible Factor-2 Alpha and Prolinhydroxylase 2 Polymorphisms in Patients with Acute Respiratory Distress Syndrome (ARDS)
por: Dötsch, Annika, et al.
Publicado: (2017)

Thromboprophylaxis with argatroban in critically ill patients with sepsis: a review
por: Bachler, Mirjam, et al.
Publicado: (2022)

Aquaporins 1, 3 and 8 expression in irritable bowel syndrome rats’ colon via NF-κB pathway
por: Chao, Guanqun, et al.
Publicado: (2017)

The Extracts of Dendrobium Alleviate Dry Eye Disease in Rat Model by Regulating Aquaporin Expression and MAPKs/NF-κB Signalling
por: Ling, Jiawei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8gr6lqc6j9p07vamdob6k4illp