Structural and biochemical basis of the formation of isoaspartate in the complementarity-determining region of antibody 64M-5 Fab

The formation of the isoaspartate (isoAsp) is one of spontaneous degradation processes of proteins, affecting their stability and activity. Here, we report for the first time the crystal structures of an antibody Fab that contains isoAsp in the complementarity-determining region (CDR), along with bi...

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Detalles Bibliográficos
Autores principales: Yokoyama, Hideshi, Mizutani, Ryuta, Noguchi, Shuji, Hayashida, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898713/
https://www.ncbi.nlm.nih.gov/pubmed/31811216
http://dx.doi.org/10.1038/s41598-019-54918-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898713/
https://www.ncbi.nlm.nih.gov/pubmed/31811216
http://dx.doi.org/10.1038/s41598-019-54918-0

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