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Structural and biochemical basis of the formation of isoaspartate in the complementarity-determining region of antibody 64M-5 Fab
The formation of the isoaspartate (isoAsp) is one of spontaneous degradation processes of proteins, affecting their stability and activity. Here, we report for the first time the crystal structures of an antibody Fab that contains isoAsp in the complementarity-determining region (CDR), along with bi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898713/ https://www.ncbi.nlm.nih.gov/pubmed/31811216 http://dx.doi.org/10.1038/s41598-019-54918-0 |