A negative feedback mechanism links UBC gene expression to ubiquitin levels by affecting RNA splicing rather than transcription

UBC gene plays a critical role in maintaining ubiquitin (Ub) homeostasis. It is upregulated under stress conditions, and herein we report that it is downregulated upon Ub overexpression. Downregulation occurs in a dose-dependent manner, suggesting the existence of a fine-tuned Ub sensing mechanism....

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Detalles Bibliográficos
Autores principales: Bianchi, Marzia, Crinelli, Rita, Giacomini, Elisa, Carloni, Elisa, Radici, Lucia, Scarpa, Emanuele-Salvatore, Tasini, Filippo, Magnani, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898720/
https://www.ncbi.nlm.nih.gov/pubmed/31811203
http://dx.doi.org/10.1038/s41598-019-54973-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898720/
https://www.ncbi.nlm.nih.gov/pubmed/31811203
http://dx.doi.org/10.1038/s41598-019-54973-7

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