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A negative feedback mechanism links UBC gene expression to ubiquitin levels by affecting RNA splicing rather than transcription
UBC gene plays a critical role in maintaining ubiquitin (Ub) homeostasis. It is upregulated under stress conditions, and herein we report that it is downregulated upon Ub overexpression. Downregulation occurs in a dose-dependent manner, suggesting the existence of a fine-tuned Ub sensing mechanism....
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898720/ https://www.ncbi.nlm.nih.gov/pubmed/31811203 http://dx.doi.org/10.1038/s41598-019-54973-7 |