Novel Screening Method Identifies PI3Kα, mTOR, and IGF1R as Key Kinases Regulating Cardiomyocyte Survival

BACKGROUND: Small molecule kinase inhibitors (KIs) are a class of agents currently used for treatment of various cancers. Unfortunately, treatment of cancer patients with some of the KIs is associated with cardiotoxicity, and there is an unmet need for methods to predict their cardiotoxicity. Here,...

Descripción completa

Detalles Bibliográficos
Autores principales: Elmadani, Manar, Khan, Suleiman, Tenhunen, Olli, Magga, Johanna, Aittokallio, Tero, Wennerberg, Krister, Kerkelä, Risto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898841/
https://www.ncbi.nlm.nih.gov/pubmed/31617439
http://dx.doi.org/10.1161/JAHA.119.013018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898841/
https://www.ncbi.nlm.nih.gov/pubmed/31617439
http://dx.doi.org/10.1161/JAHA.119.013018

Ejemplares similares