Drug screens of NGLY1 deficiency in worm and fly models reveal catecholamine, NRF2 and anti-inflammatory-pathway activation as potential clinical approaches

N-glycanase 1 (NGLY1) deficiency is an ultra-rare and complex monogenic glycosylation disorder that affects fewer than 40 patients globally. NGLY1 deficiency has been studied in model organisms such as yeast, worms, flies and mice. Proteasomal and mitochondrial homeostasis gene networks are controll...

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Detalles Bibliográficos
Autores principales: Iyer, Sangeetha, Mast, Joshua D., Tsang, Hillary, Rodriguez, Tamy P., DiPrimio, Nina, Prangley, Madeleine, Sam, Feba S., Parton, Zachary, Perlstein, Ethan O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899034/
https://www.ncbi.nlm.nih.gov/pubmed/31615832
http://dx.doi.org/10.1242/dmm.040576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899034/
https://www.ncbi.nlm.nih.gov/pubmed/31615832
http://dx.doi.org/10.1242/dmm.040576

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