Structural basis of antagonism of human APOBEC3F by HIV-1 Vif

HIV-1 Vif promotes degradation of the antiviral APOBEC3 (A3) proteins through the host ubiquitin-proteasome pathway to enable viral immune evasion. Disrupting Vif-A3 interactions to reinstate the A3-catalyzed suppression of HIV-1 replication is a potential approach for antiviral therapeutics. Howeve...

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Detalles Bibliográficos
Autores principales: Hu, Yingxia, Desimmie, Belete A., Nguyen, Henry C., Ziegler, Samantha J., Cheng, Tat Cheung, Chen, John, Wang, Jia, Wang, Hongwei, Zhang, Kai, Pathak, Vinay K., Xiong, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899190/
https://www.ncbi.nlm.nih.gov/pubmed/31792451
http://dx.doi.org/10.1038/s41594-019-0343-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899190/
https://www.ncbi.nlm.nih.gov/pubmed/31792451
http://dx.doi.org/10.1038/s41594-019-0343-6

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