Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody

The HIV-1 envelope (Env) glycoprotein, a (gp120-gp41)(3) trimer, mediates fusion of viral and host cell membranes after gp120 binding to host receptor CD4. Receptor binding triggers conformational changes allowing coreceptor (CCR5) recognition through CCR5’s tyrosine-sulfated N-terminus, release of...

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Detalles Bibliográficos
Autores principales: Yang, Zhi, Wang, Haoqing, Liu, Albert Z., Gristick, Harry B., Bjorkman, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899201/
https://www.ncbi.nlm.nih.gov/pubmed/31792452
http://dx.doi.org/10.1038/s41594-019-0344-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899201/
https://www.ncbi.nlm.nih.gov/pubmed/31792452
http://dx.doi.org/10.1038/s41594-019-0344-5

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