RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction

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Acute myeloid leukemia (AML) is associated with mutations in transcriptional and epigenetic regulator genes impairing myeloid differentiation. The t(8;21)(q22;q22) translocation generates the RUNX1-ETO fusion protein, which interferes with the hematopoietic master regulator RUNX1. We previously show...

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Detalles Bibliográficos
Autores principales: Ptasinska, Anetta, Pickin, Anna, Assi, Salam A., Chin, Paulynn Suyin, Ames, Luke, Avellino, Roberto, Gröschel, Stefan, Delwel, Ruud, Cockerill, Peter N., Osborne, Cameron S., Bonifer, Constanze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899442/
https://www.ncbi.nlm.nih.gov/pubmed/31533028
http://dx.doi.org/10.1016/j.celrep.2019.08.040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899442/
https://www.ncbi.nlm.nih.gov/pubmed/31533028
http://dx.doi.org/10.1016/j.celrep.2019.08.040

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