Side Chain Orientation of Tryptophan Analogues Determines Agonism and Inverse Agonism in Short Ghrelin Peptides

We describe two synthetic amino acids with inverted side chain stereochemistry, which induce opposite biological activity. Phe(4) is an important part of the activation motif of ghrelin, and in short peptide inverse agonists such as KwFwLL‐NH(2), the aromatic core is necessary for inactivation of th...

Descripción completa

Detalles Bibliográficos
Autores principales: Nicke, Lennart, Müller, Ronny, Geyer, Armin, Els‐Heindl, Sylvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899459/
https://www.ncbi.nlm.nih.gov/pubmed/31442005
http://dx.doi.org/10.1002/cmdc.201900409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899459/
https://www.ncbi.nlm.nih.gov/pubmed/31442005
http://dx.doi.org/10.1002/cmdc.201900409

Ejemplares similares