Substituted Aminoacetamides as Novel Leads for Malaria Treatment

Herein we describe the optimization of a phenotypic hit against Plasmodium falciparum based on an aminoacetamide scaffold. This led to N‐(3‐chloro‐4‐fluorophenyl)‐2‐methyl‐2‐{[4‐methyl‐3‐(morpholinosulfonyl)phenyl]amino}propanamide (compound 28) with low‐nanomolar activity against the intraerythrocy...

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Detalles Bibliográficos
Autores principales: Norcross, Neil R., Wilson, Caroline, Baragaña, Beatriz, Hallyburton, Irene, Osuna‐Cabello, Maria, Norval, Suzanne, Riley, Jennifer, Fletcher, Daniel, Sinden, Robert, Delves, Michael, Ruecker, Andrea, Duffy, Sandra, Meister, Stephan, Antonova‐Koch, Yevgeniya, Crespo, Benigno, de Cózar, Cristina, Sanz, Laura M., Gamo, Francisco Javier, Avery, Vicky M., Frearson, Julie A., Gray, David W., Fairlamb, Alan H., Winzeler, Elizabeth A., Waterson, David, Campbell, Simon F., Willis, Paul A., Read, Kevin D., Gilbert, Ian H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899483/
https://www.ncbi.nlm.nih.gov/pubmed/31188540
http://dx.doi.org/10.1002/cmdc.201900329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899483/
https://www.ncbi.nlm.nih.gov/pubmed/31188540
http://dx.doi.org/10.1002/cmdc.201900329

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