Efficient CRISPR/Cas9-Mediated Gene Knockin in Mouse Hematopoietic Stem and Progenitor Cells

Mutations accumulating in hematopoietic stem and progenitor cells (HSPCs) during development can cause severe hematological disorders. Modeling these mutations in mice is essential for understanding their functional consequences. Here, we describe an efficient CRISPR/Cas9-based system to knock in an...

Descripción completa

Detalles Bibliográficos
Autores principales: Tran, Ngoc Tung, Sommermann, Thomas, Graf, Robin, Trombke, Janine, Pempe, Jenniffer, Petsch, Kerstin, Kühn, Ralf, Rajewsky, Klaus, Chu, Van Trung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899516/
https://www.ncbi.nlm.nih.gov/pubmed/31553918
http://dx.doi.org/10.1016/j.celrep.2019.08.065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899516/
https://www.ncbi.nlm.nih.gov/pubmed/31553918
http://dx.doi.org/10.1016/j.celrep.2019.08.065

Ejemplares similares