Copper‐Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes

A copper‐catalyzed silylation of propargyl dichlorides was developed to access chloro‐substituted allenylsilanes under mild reaction conditions. Moreover, enantioenriched chloro‐substituted allenylsilanes can be synthesized in moderate to high yields and good enantioselectivities with this protocol....

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Detalles Bibliográficos
Autores principales: Liu, Zheng‐Li, Yang, Chao, Xue, Qi‐Yan, Zhao, Meng, Shan, Cui‐Cui, Xu, Yun‐He, Loh, Teck‐Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899605/
https://www.ncbi.nlm.nih.gov/pubmed/31532868
http://dx.doi.org/10.1002/anie.201908343
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author Liu, Zheng‐Li
Yang, Chao
Xue, Qi‐Yan
Zhao, Meng
Shan, Cui‐Cui
Xu, Yun‐He
Loh, Teck‐Peng
author_facet Liu, Zheng‐Li
Yang, Chao
Xue, Qi‐Yan
Zhao, Meng
Shan, Cui‐Cui
Xu, Yun‐He
Loh, Teck‐Peng
author_sort Liu, Zheng‐Li
collection PubMed
description A copper‐catalyzed silylation of propargyl dichlorides was developed to access chloro‐substituted allenylsilanes under mild reaction conditions. Moreover, enantioenriched chloro‐substituted allenylsilanes can be synthesized in moderate to high yields and good enantioselectivities with this protocol.
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spelling pubmed-68996052019-12-19 Copper‐Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes Liu, Zheng‐Li Yang, Chao Xue, Qi‐Yan Zhao, Meng Shan, Cui‐Cui Xu, Yun‐He Loh, Teck‐Peng Angew Chem Int Ed Engl Communications A copper‐catalyzed silylation of propargyl dichlorides was developed to access chloro‐substituted allenylsilanes under mild reaction conditions. Moreover, enantioenriched chloro‐substituted allenylsilanes can be synthesized in moderate to high yields and good enantioselectivities with this protocol. John Wiley and Sons Inc. 2019-10-04 2019-11-11 /pmc/articles/PMC6899605/ /pubmed/31532868 http://dx.doi.org/10.1002/anie.201908343 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Liu, Zheng‐Li
Yang, Chao
Xue, Qi‐Yan
Zhao, Meng
Shan, Cui‐Cui
Xu, Yun‐He
Loh, Teck‐Peng
Copper‐Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes
title Copper‐Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes
title_full Copper‐Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes
title_fullStr Copper‐Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes
title_full_unstemmed Copper‐Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes
title_short Copper‐Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes
title_sort copper‐catalyzed asymmetric silylation of propargyl dichlorides: access to enantioenriched functionalized allenylsilanes
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899605/
https://www.ncbi.nlm.nih.gov/pubmed/31532868
http://dx.doi.org/10.1002/anie.201908343
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