Cargando…

Exosomal Transport of Hepatocyte‐Derived Drug‐Modified Proteins to the Immune System

Idiosyncratic drug‐induced liver injury (DILI) is a rare, often difficult‐to‐predict adverse reaction with complex pathomechanisms. However, it is now evident that certain forms of DILI are immune‐mediated and may involve the activation of drug‐specific T cells. Exosomes are cell‐derived vesicles th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ogese, Monday O., Jenkins, Rosalind E., Adair, Kareena, Tailor, Arun, Meng, Xiaoli, Faulkner, Lee, Enyindah, Bright O., Schofield, Amy, Diaz‐Nieto, Rafael, Ressel, Lorenzo, Eagle, Gina L., Kitteringham, Neil R., Goldring, Chris E., Park, B. Kevin, Naisbitt, Dean J., Betts, Catherine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899733/ https://www.ncbi.nlm.nih.gov/pubmed/31070244 http://dx.doi.org/10.1002/hep.30701

Ejemplares similares

Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01
por: Gardner, Joshua, et al.
Publicado: (2022)

Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System
por: Ali, Serat-E, et al.
Publicado: (2023)

HLA-DQ restricted activation of nitroso-sulfamethoxazole-specific CD4+ T-lymphocytes
por: Ogese, Monday, et al.
Publicado: (2014)

Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01
por: Ogese, Monday O, et al.
Publicado: (2021)

Negative regulation by Programmed Death Ligand-1 during drug-specific priming of T-cells and the influence of Programmed Death-1 on effector T-cell function
por: Gibson, Andrew, et al.
Publicado: (2014)

Shared Clavulanate and Tazobactam Antigenic Determinants Activate T-Cells from Hypersensitive Patients
por: Ariza, Adriana, et al.
Publicado: (2022)

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation
por: Rowe, Cliff, et al.
Publicado: (2013)

Abs No: HLA-A*31:01 positive hypersensitive patient
por: Lichtenfels, Maike, et al.
Publicado: (2014)

Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01
por: Zhao, Qing, et al.
Publicado: (2019)

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes
por: Baxter, Melissa, et al.
Publicado: (2015)

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications
por: Walsh, Joanne, et al.
Publicado: (2014)

Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney
por: Shelton, Luke M., et al.
Publicado: (2015)

Total Proteome Analysis Identifies Migration Defects as a Major Pathogenetic Factor in Immunoglobulin Heavy Chain Variable Region (IGHV)-unmutated Chronic Lymphocytic Leukemia
por: Eagle, Gina L., et al.
Publicado: (2015)

Assessing technical and biological variation in SWATH-MS-based proteomic analysis of chronic lymphocytic leukaemia cells
por: Eagle, Gina L., et al.
Publicado: (2021)

Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research
por: Evans, Jonathan P, et al.
Publicado: (2019)

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
por: Bell, Catherine C., et al.
Publicado: (2016)

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway
por: Copple, Ian M., et al.
Publicado: (2010)

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile
por: Heslop, James A., et al.
Publicado: (2016)

Activation of human CD8+ T-cells with nitroso dapsone-modified HLA-B*13:01-binding peptides()
por: Almutairi, Mubarak, et al.
Publicado: (2023)

Donor‐Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte‐Like Cells
por: Heslop, James A., et al.
Publicado: (2017)

Exosome-Mimetic Nanovesicles from Hepatocytes promote hepatocyte proliferation in vitro and liver regeneration in vivo
por: Wu, Jun-Yi, et al.
Publicado: (2018)

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver
por: Kitteringham, Neil R., et al.
Publicado: (2010)

Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB()
por: Chia, Alvin J.L., et al.
Publicado: (2010)

Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification
por: Howell, Lawrence, et al.
Publicado: (2021)

Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes
por: Nojima, Hiroyuki, et al.
Publicado: (2016)

Exosomes from mesenchymal stem cells induce the conversion of hepatocytes into progenitor oval cells
por: Wu, Hao-Hsiang, et al.
Publicado: (2017)

TMAO-Activated Hepatocyte-Derived Exosomes Impair Angiogenesis via Repressing CXCR4
por: Liu, Xiang, et al.
Publicado: (2022)

Characterization of Flucloxacillin-specific CD8+ T-cells in a mouse model
por: Nattrass, Ryan, et al.
Publicado: (2014)

MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity
por: Kia, Richard, et al.
Publicado: (2015)

T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab
por: Hammond, Sean, et al.
Publicado: (2021)

Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury
por: Ali, Serat-E, et al.
Publicado: (2023)

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication
por: Sison-Young, Rowena L. C., et al.
Publicado: (2015)

Hepatocyte-derived exosomal MiR-194 activates PMVECs and promotes angiogenesis in hepatopulmonary syndrome
por: Chen, Lin, et al.
Publicado: (2019)

In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs
por: Hammond, Sean, et al.
Publicado: (2021)

Why drug exposure is frequently associated with T-cell mediated cutaneous hypersensitivity reactions
por: Line, James, et al.
Publicado: (2023)

The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer
por: Evans, Jonathan P., et al.
Publicado: (2018)

Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer
por: Evans, Jonathan P., et al.
Publicado: (2019)

The application of cytokeratin-18 as a biomarker for drug-induced liver injury
por: Korver, Samantha, et al.
Publicado: (2021)

Characterization of primary human T-cell responses to p-phenylenediamine and Bandrowski's base
por: Gibson, Andrew, et al.
Publicado: (2014)

Exogenous exosomes from mice with acetaminophen-induced liver injury promote toxicity in the recipient hepatocytes and mice
por: Cho, Young-Eun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_sf4vmh61vs6793bukthe972d5f