Enhancing Potency and Selectivity of a DC‐SIGN Glycomimetic Ligand by Fragment‐Based Design: Structural Basis

Chemical modification of pseudo‐dimannoside ligands guided by fragment‐based design allowed for the exploitation of an ammonium‐binding region in the vicinity of the mannose‐binding site of DC‐SIGN, leading to the synthesis of a glycomimetic antagonist (compound 16) of unprecedented affinity and sel...

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Detalles Bibliográficos
Autores principales: Medve, Laura, Achilli, Silvia, Guzman‐Caldentey, Joan, Thépaut, Michel, Senaldi, Luca, Le Roy, Aline, Sattin, Sara, Ebel, Christine, Vivès, Corinne, Martin‐Santamaria, Sonsoles, Bernardi, Anna, Fieschi, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899773/
https://www.ncbi.nlm.nih.gov/pubmed/31469191
http://dx.doi.org/10.1002/chem.201903391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899773/
https://www.ncbi.nlm.nih.gov/pubmed/31469191
http://dx.doi.org/10.1002/chem.201903391

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