C‐terminal Cysteines of CueR Act as Auxiliary Metal Site Ligands upon Hg(II) Binding—A Mechanism To Prevent Transcriptional Activation by Divalent Metal Ions?

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Intracellular Cu(I) is controlled by the transcriptional regulator CueR, which effectively discriminates between monovalent and divalent metal ions. It is intriguing that Hg(II) does not activate transcription, as bis‐thiolate metal sites exhibit high affinity for Hg(II). Here the binding of Hg(II)...

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Detalles Bibliográficos
Autores principales: Balogh, Ria K., Gyurcsik, Béla, Hunyadi‐Gulyás, Éva, Schell, Juliana, Thulstrup, Peter W., Hemmingsen, Lars, Jancsó, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899792/
https://www.ncbi.nlm.nih.gov/pubmed/31365771
http://dx.doi.org/10.1002/chem.201902940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899792/
https://www.ncbi.nlm.nih.gov/pubmed/31365771
http://dx.doi.org/10.1002/chem.201902940

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