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Age‐ and disease‐specific changes of the kynurenine pathway in Parkinson’s and Alzheimer’s disease

The kynurenine (Kyn) pathway, which regulates neuroinflammation and N‐methyl‐d‐aspartate receptor activation, is implicated in Parkinson’s disease (PD) and Alzheimer’s disease (AD). Age‐related changes in Kyn metabolism and altered cerebral Kyn uptake along large neutral amino acid transporters, cou...

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Detalles Bibliográficos
Autores principales: Sorgdrager, Freek J. H., Vermeiren, Yannick, Van Faassen, Martijn, van der Ley, Claude, Nollen, Ellen A. A., Kema, Ido P., De Deyn, Peter P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899862/
https://www.ncbi.nlm.nih.gov/pubmed/31376341
http://dx.doi.org/10.1111/jnc.14843