Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß

The Hedgehog (Hh) signaling pathway is crucial for vertebrate embryonic development, tissue homeostasis and regeneration. Hh signaling is upregulated in basal cell carcinoma and medulloblastoma and Hh pathway inhibitors targeting the Smoothened (SMO) protein are in clinical use. However, the signali...

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Detalles Bibliográficos
Autores principales: Kremer, Lea, Hennes, Elisabeth, Brause, Alexandra, Ursu, Andrei, Robke, Lucas, Matsubayashi, Hideaki T., Nihongaki, Yuta, Flegel, Jana, Mejdrová, Ivana, Eickhoff, Jan, Baumann, Matthias, Nencka, Radim, Janning, Petra, Kordes, Susanne, Schöler, Hans R., Sterneckert, Jared, Inoue, Takanari, Ziegler, Slava, Waldmann, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900058/
https://www.ncbi.nlm.nih.gov/pubmed/31454140
http://dx.doi.org/10.1002/anie.201907632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900058/
https://www.ncbi.nlm.nih.gov/pubmed/31454140
http://dx.doi.org/10.1002/anie.201907632

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