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Ara h 7 isoforms share many linear epitopes: Are 3D epitopes crucial to elucidate divergent abilities?

BACKGROUND: The peanut allergens Ara h 2, h 6, and h 7 are potent allergens and can trigger severe reactions. Ara h 7 consists of three isoforms differing in their ability to induce basophil degranulation, whereas the ability of Ara h 7.0201 is comparable to Ara h 2 and 6 as shown in previous litera...

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Detalles Bibliográficos
Autores principales: Ehlers, Anna M., Klinge, Marco, Suer, Waltraud, Weimann, Yvonne, Knulst, André C., Besa, Frithjof, Le, Thuy‐My, Otten, Henny G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900131/
https://www.ncbi.nlm.nih.gov/pubmed/31520442
http://dx.doi.org/10.1111/cea.13496