Cargando…

Immunome perturbation is present in patients with juvenile idiopathic arthritis who are in remission and will relapse upon anti-TNFα withdrawal

OBJECTIVES: Biologics treatment with antitumour necrosis factor alpha (TNFα) is efficacious in patients with juvenile idiopathic arthritis (JIA). Despite displaying clinical inactivity during treatment, many patients will flare on cessation of therapy. The inability to definitively discriminate pati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leong, Jing Yao, Chen, Phyllis, Yeo, Joo Guan, Ally, Fauziah, Chua, Camillus, Nur Hazirah, Sharifah, Poh, Su Li, Pan, Lu, Lai, Liyun, Lee, Elene Seck Choon, Bathi, Loshinidevi D/O Thana, Arkachaisri, Thaschawee, Lovell, Daniel, Albani, Salvatore
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2019
Materias:	Paediatric Rheumatology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900250/ https://www.ncbi.nlm.nih.gov/pubmed/31540934 http://dx.doi.org/10.1136/annrheumdis-2019-216059

Ejemplares similares

Systemic Sclerosis Perturbs the Architecture of the Immunome
por: Paleja, Bhairav, et al.
Publicado: (2020)

Immunomics in Pediatric Rheumatic Diseases
por: Tay, Shi Huan, et al.
Publicado: (2019)

Secukinumab in enthesitis-related arthritis and juvenile psoriatic arthritis: a randomised, double-blind, placebo-controlled, treatment withdrawal, phase 3 trial
por: Brunner, Hermine I, et al.
Publicado: (2023)

Prevention of disease flares by risk-adapted stratification of therapy withdrawal in juvenile idiopathic arthritis: results from the PREVENT-JIA trial
por: Gerss, Joachim, et al.
Publicado: (2022)

Proinflammatory IL-17 pathways dominate the architecture of the immunome in pediatric refractory epilepsy
por: Kumar, Pavanish, et al.
Publicado: (2019)

Prevalence of autoimmune diseases and other associated conditions in children and young adults with juvenile idiopathic arthritis
por: Lovell, Daniel J, et al.
Publicado: (2021)

Timing matters: real-world effectiveness of early combination of biologic and conventional synthetic disease-modifying antirheumatic drugs for treating newly diagnosed polyarticular course juvenile idiopathic arthritis
por: Huang, Bin, et al.
Publicado: (2020)

Pro-Inflammatory Derangement of the Immuno-Interactome in Heart Failure
por: Kumar, Pavanish, et al.
Publicado: (2022)

Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
por: Ravelli, Angelo, et al.
Publicado: (2016)

A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19
por: Yeo, Joo Guan, et al.
Publicado: (2021)

Malignancy incidence in 5294 patients with juvenile arthritis
por: Zahedi Niaki, Omid, et al.
Publicado: (2016)

The majority of newly diagnosed patients with juvenile idiopathic arthritis reach an inactive disease state within the first year of specialised care: data from a German inception cohort
por: Sengler, Claudia, et al.
Publicado: (2015)

Biological treatment in systemic juvenile idiopathic arthritis: achievement of inactive disease or clinical remission on a first, second or third biological agent
por: Woerner, A, et al.
Publicado: (2015)

Juvenile idiopathic arthritis in adulthood: fulfilment of classification criteria for adult rheumatic diseases, long-term outcomes and predictors of inactive disease, functional status and damage
por: Oliveira-Ramos, Filipa, et al.
Publicado: (2016)

Tocilizumab in the treatment of mixed connective tissue disease and overlap syndrome in children
por: Cabrera, Natalia, et al.
Publicado: (2016)

Decreased CD3-CD16+CD56+ natural killer cell counts in children with orbital myositis: a clue to disease activity
por: Briones, Melissa R, et al.
Publicado: (2017)

ProNGF-p75NTR axis plays a proinflammatory role in inflamed joints: a novel pathogenic mechanism in chronic arthritis
por: Minnone, Gaetana, et al.
Publicado: (2017)

Chronic and recurrent non-infectious paediatric-onset uveitis: a French cohort
por: Morelle, Guillaume, et al.
Publicado: (2019)

Growing up with chronic arthritis: the confusing matter of classification
por: Guillaume-Czitrom, Séverine, et al.
Publicado: (2017)

ADA2 deficiency: case report of a new phenotype and novel mutation in two sisters
por: Uettwiller, F, et al.
Publicado: (2016)

Validating 10-joint juvenile arthritis disease activity score cut-offs for disease activity levels in non-systemic juvenile idiopathic arthritis
por: Backström, Maria, et al.
Publicado: (2019)

Genomic risk scores for juvenile idiopathic arthritis and its subtypes
por: Cánovas, Rodrigo, et al.
Publicado: (2020)

Arthropathy of Down syndrome: an under-diagnosed inflammatory joint disease that warrants a name change
por: Foley, Charlene M, et al.
Publicado: (2019)

Juvenile idiopathic arthritis and risk of cancer before and after the introduction of biological therapies
por: Horne, AnnaCarin, et al.
Publicado: (2019)

Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms
por: López-Isac, Elena, et al.
Publicado: (2021)

Development and reliability of a novel ultrasonographic joint-specific scoring system for synovitis with reference atlas for patients with juvenile idiopathic arthritis
por: Sande, Nina Krafft, et al.
Publicado: (2021)

Efficacy and safety of belimumab in paediatric and adult patients with systemic lupus erythematosus: an across-study comparison
por: Brunner, Hermine I, et al.
Publicado: (2021)

Serum calprotectin (S100A8/A9): a promising biomarker in diagnosis and follow-up in different subgroups of juvenile idiopathic arthritis
por: La, Céline, et al.
Publicado: (2021)

Health-related quality of life and disability in adults with juvenile idiopathic arthritis: comparison with adult-onset rheumatic diseases
por: Oliveira Ramos, Filipa, et al.
Publicado: (2021)

Drivers of non-zero physician global scores during periods of inactive disease in juvenile idiopathic arthritis
por: Alongi, Alessandra, et al.
Publicado: (2022)

Clinical manifestations and outcome of SARS-CoV-2 infections in children and adolescents with rheumatic musculoskeletal diseases: data from the National Paediatric Rheumatology Database in Germany
por: Sengler, Claudia, et al.
Publicado: (2021)

Procedures for the content, conduct and format of EULAR/PReS paediatric musculoskeletal ultrasound courses
por: Magni-Manzoni, Silvia, et al.
Publicado: (2022)

Medication burden in young adults with juvenile idiopathic arthritis: data from a multicentre observational study
por: Montag, Laura J, et al.
Publicado: (2022)

Complications of complications: diagnosis and treatment of recurrent macrophage activation syndrome in a patient with well-controlled systemic juvenile idiopathic arthritis
por: Macaraeg, Marci, et al.
Publicado: (2023)

Methotrexate therapy associated with a reduced rate of new-onset uveitis in patients with biological-naïve juvenile idiopathic arthritis
por: van Straalen, Joeri W, et al.
Publicado: (2023)

Associations between power Doppler ultrasound findings and B-mode synovitis and clinical arthritis in juvenile idiopathic arthritis using a standardised scanning approach and scoring system
por: Sande, Nina Krafft, et al.
Publicado: (2023)

Patterns of clinical joint inflammation in juvenile idiopathic arthritis
por: Heckert, Sascha L, et al.
Publicado: (2023)

Antibiotic exposure in prenatal and early life and risk of juvenile idiopathic arthritis: a nationwide register-based cohort study
por: Hestetun, Sigrid, et al.
Publicado: (2023)

Children with extended oligoarticular and polyarticular juvenile idiopathic arthritis have alterations in B and T follicular cell subsets in peripheral blood and a cytokine profile sustaining B cell activation
por: Tomé, Catarina, et al.
Publicado: (2023)

Lengthening sleep reduces pain in childhood arthritis: a crossover randomised controlled trial
por: Clairman, Hayyah, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_1ngb4qgcrk3sr2csnma0mo6dhr