Mechanism of ribosome stalling during translation of a poly(A) tail

Faulty or damaged mRNAs are detected by the cell when translating ribosomes stall during elongation and trigger pathways of mRNA decay, nascent protein degradation, and ribosome recycling. The most common mRNA defect in eukaryotes is probably inappropriate poly-adenylation at near-cognate sites with...

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Detalles Bibliográficos
Autores principales: Chandrasekaran, Viswanathan, Juszkiewicz, Szymon, Choi, Junhong, Puglisi, Joseph D., Brown, Alan, Shao, Sichen, Ramakrishnan, V., Hegde, Ramanujan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900289/
https://www.ncbi.nlm.nih.gov/pubmed/31768042
http://dx.doi.org/10.1038/s41594-019-0331-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900289/
https://www.ncbi.nlm.nih.gov/pubmed/31768042
http://dx.doi.org/10.1038/s41594-019-0331-x

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