The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance, and neuronal survival in mice

Proteasome-mediated degradation of intracellular proteins is essential for cell function and survival. The proteasome-binding protein PI31 (Proteasomal Inhibitor of 31kD) promotes 26S assembly and functions as an adapter for proteasome transport in axons. As localized protein synthesis and degradati...

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Detalles Bibliográficos
Autores principales: Minis, Adi, Rodriguez, Jose A., Levin, Avi, Liu, Kai, Govek, Eve-Ellen, Hatten, Mary E., Steller, Hermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900516/
https://www.ncbi.nlm.nih.gov/pubmed/31754024
http://dx.doi.org/10.1073/pnas.1911921116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900516/
https://www.ncbi.nlm.nih.gov/pubmed/31754024
http://dx.doi.org/10.1073/pnas.1911921116

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