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The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance, and neuronal survival in mice
Proteasome-mediated degradation of intracellular proteins is essential for cell function and survival. The proteasome-binding protein PI31 (Proteasomal Inhibitor of 31kD) promotes 26S assembly and functions as an adapter for proteasome transport in axons. As localized protein synthesis and degradati...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900516/ https://www.ncbi.nlm.nih.gov/pubmed/31754024 http://dx.doi.org/10.1073/pnas.1911921116 |