Immunosuppressant mycophenolic acid biosynthesis employs a new globin-like enzyme for prenyl side chain cleavage

Mycophenolic acid (MPA, 1) and its derivatives are first-line immunosuppressants used in organ transplantation and for treating autoimmune diseases. Despite chemical synthetic achievements, the biosynthetic formation of a seven-carbon carboxylic acid pharmacophore side chain of 1, especially the pro...

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Detalles Bibliográficos
Autores principales: Chen, Xiwei, Wang, Lu, Zhang, Jinmei, Jiang, Tao, Hu, Changhua, Li, Dehai, Zou, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900556/
https://www.ncbi.nlm.nih.gov/pubmed/31867170
http://dx.doi.org/10.1016/j.apsb.2019.06.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900556/
https://www.ncbi.nlm.nih.gov/pubmed/31867170
http://dx.doi.org/10.1016/j.apsb.2019.06.009

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