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Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria
Oligoribonucleases are conserved enzymes that degrade short RNA molecules of up to 5 nt in length and are assumed to constitute the final stage of RNA turnover. Here we demonstrate that REXO2 is a specialized dinucleotide-degrading enzyme that shows no preference between RNA and DNA dinucleotide sub...
Autores principales: | Nicholls, Thomas J., Spåhr, Henrik, Jiang, Shan, Siira, Stefan J., Koolmeister, Camilla, Sharma, Sushma, Kauppila, Johanna H.K., Jiang, Min, Kaever, Volkhard, Rackham, Oliver, Chabes, Andrei, Falkenberg, Maria, Filipovska, Aleksandra, Larsson, Nils-Göran, Gustafsson, Claes M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900737/ https://www.ncbi.nlm.nih.gov/pubmed/31588022 http://dx.doi.org/10.1016/j.molcel.2019.09.010 |
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