Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy

Medulloblastoma (MB), the most frequent malignant childhood brain tumor, can arise from cellular malfunctions during hindbrain development. Here we generate humanized models for Sonic Hedgehog (SHH)-subgroup MB via MYCN overexpression in primary human hindbrain-derived neuroepithelial stem (hbNES) c...

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Detalles Bibliográficos
Autores principales: Čančer, Matko, Hutter, Sonja, Holmberg, Karl O., Rosén, Gabriela, Sundström, Anders, Tailor, Jignesh, Bergström, Tobias, Garancher, Alexandra, Essand, Magnus, Wechsler-Reya, Robert J., Falk, Anna, Weishaupt, Holger, Swartling, Fredrik J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900751/
https://www.ncbi.nlm.nih.gov/pubmed/31786016
http://dx.doi.org/10.1016/j.stem.2019.10.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900751/
https://www.ncbi.nlm.nih.gov/pubmed/31786016
http://dx.doi.org/10.1016/j.stem.2019.10.005

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