URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion

BACKGROUND: Previous studies reported that URB597 (URB) had therapeutic potential for treating chronic cerebral hypoperfusion (CCH)-induced neuroinflammation and autophagy dysfunction. However, the interaction mechanisms underlying the CCH-induced abnormal excessive autophagy and neuroinflammation r...

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Detalles Bibliográficos
Autores principales: Su, Shao-Hua, Wu, Yi-Fang, Lin, Qi, Wang, Da-Peng, Hai, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900848/
https://www.ncbi.nlm.nih.gov/pubmed/31815636
http://dx.doi.org/10.1186/s12974-019-1668-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900848/
https://www.ncbi.nlm.nih.gov/pubmed/31815636
http://dx.doi.org/10.1186/s12974-019-1668-0

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