Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression

Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg) cells and the dual roles of FOXP proteins as a...

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Autores principales: Kim, Ju-Ha, Hwang, Jisung, Jung, Ji Hoon, Lee, Hyo-Jung, Lee, Dae Young, Kim, Sung-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900861/
https://www.ncbi.nlm.nih.gov/pubmed/31815635
http://dx.doi.org/10.1186/s12943-019-1110-3
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author Kim, Ju-Ha
Hwang, Jisung
Jung, Ji Hoon
Lee, Hyo-Jung
Lee, Dae Young
Kim, Sung-Hoon
author_facet Kim, Ju-Ha
Hwang, Jisung
Jung, Ji Hoon
Lee, Hyo-Jung
Lee, Dae Young
Kim, Sung-Hoon
author_sort Kim, Ju-Ha
collection PubMed
description Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg) cells and the dual roles of FOXP proteins as an oncogene or a tumor suppressor are unclear and controversial in cancers to date. Thus, the present review highlighted research history, dual roles of FOXP proteins as a tumor suppressor or an oncogene, their molecular networks with other proteins and noncoding RNAs, cellular immunotherapy targeting FOXP3, and clinical implications in cancer progression.
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spelling pubmed-69008612019-12-11 Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression Kim, Ju-Ha Hwang, Jisung Jung, Ji Hoon Lee, Hyo-Jung Lee, Dae Young Kim, Sung-Hoon Mol Cancer Review Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg) cells and the dual roles of FOXP proteins as an oncogene or a tumor suppressor are unclear and controversial in cancers to date. Thus, the present review highlighted research history, dual roles of FOXP proteins as a tumor suppressor or an oncogene, their molecular networks with other proteins and noncoding RNAs, cellular immunotherapy targeting FOXP3, and clinical implications in cancer progression. BioMed Central 2019-12-09 /pmc/articles/PMC6900861/ /pubmed/31815635 http://dx.doi.org/10.1186/s12943-019-1110-3 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Kim, Ju-Ha
Hwang, Jisung
Jung, Ji Hoon
Lee, Hyo-Jung
Lee, Dae Young
Kim, Sung-Hoon
Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
title Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
title_full Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
title_fullStr Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
title_full_unstemmed Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
title_short Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
title_sort molecular networks of foxp family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900861/
https://www.ncbi.nlm.nih.gov/pubmed/31815635
http://dx.doi.org/10.1186/s12943-019-1110-3
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