Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice

CX3CR1 is a chemokine receptor expressed on microglia that binds Fractalkine (CX3CL1) and regulates microglial recruitment to sites of neuroinflammation. Full deletion of CX3CR1 in mouse models of Alzheimer's disease have opposing effects on amyloid-β and tau pathologies raising concerns about...

Descripción completa

Detalles Bibliográficos
Autores principales: Hickman, Suzanne E., Allison, Elizabeth K., Coleman, Uwanda, Kingery-Gallagher, Nathan D., El Khoury, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900980/
https://www.ncbi.nlm.nih.gov/pubmed/31849963
http://dx.doi.org/10.3389/fimmu.2019.02780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900980/
https://www.ncbi.nlm.nih.gov/pubmed/31849963
http://dx.doi.org/10.3389/fimmu.2019.02780

Ejemplares similares