ERAP1 enzyme-mediated trimming and structural analyses of MHC I–bound precursor peptides yield novel insights into antigen processing and presentation

Endoplasmic reticulum aminopeptidase 1 (ERAP1) and ERAP2 critically shape the major histocompatibility complex I (MHC I) immunopeptidome. The ERAPs remove N-terminal residues from antigenic precursor peptides and generate optimal-length peptides (i.e. 8–10-mers) to fit into the MHC class I groove. I...

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Detalles Bibliográficos
Autores principales: Li, Lenong, Batliwala, Mansoor, Bouvier, Marlene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901306/
https://www.ncbi.nlm.nih.gov/pubmed/31601650
http://dx.doi.org/10.1074/jbc.RA119.010102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901306/
https://www.ncbi.nlm.nih.gov/pubmed/31601650
http://dx.doi.org/10.1074/jbc.RA119.010102

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