Variation in zygotic CRISPR/Cas9 gene editing outcomes generates novel reporter and deletion alleles at the Gdf11 locus

Recent advances in CRISPR/Cas gene editing technology have significantly expanded the possibilities and accelerated the pace of creating genetically engineered animal models. However, CRISPR/Cas-based strategies designed to precisely edit the genome can often yield unintended outcomes. Here, we repo...

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Bibliographic Details
Main Authors: Goldstein, Jill M., Valido, Austin, Lewandowski, Jordan P., Walker, Ryan G., Mills, Melanie J., Messemer, Kathleen A., Besseling, Paul, Lee, Kyu Ha, Wattrus, Samuel J., Cho, Miook, Lee, Richard T., Wagers, Amy J.
Format: Online Article Text
Language:English
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901511/
https://www.ncbi.nlm.nih.gov/pubmed/31819086
http://dx.doi.org/10.1038/s41598-019-54766-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901511/
https://www.ncbi.nlm.nih.gov/pubmed/31819086
http://dx.doi.org/10.1038/s41598-019-54766-y

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