Variation in zygotic CRISPR/Cas9 gene editing outcomes generates novel reporter and deletion alleles at the Gdf11 locus

Recent advances in CRISPR/Cas gene editing technology have significantly expanded the possibilities and accelerated the pace of creating genetically engineered animal models. However, CRISPR/Cas-based strategies designed to precisely edit the genome can often yield unintended outcomes. Here, we repo...

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Detalles Bibliográficos
Autores principales: Goldstein, Jill M., Valido, Austin, Lewandowski, Jordan P., Walker, Ryan G., Mills, Melanie J., Messemer, Kathleen A., Besseling, Paul, Lee, Kyu Ha, Wattrus, Samuel J., Cho, Miook, Lee, Richard T., Wagers, Amy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901511/
https://www.ncbi.nlm.nih.gov/pubmed/31819086
http://dx.doi.org/10.1038/s41598-019-54766-y

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