Oxidation and alkylation stresses activate ribosome-quality control

Oxidation and alkylation of nucleobases are known to disrupt their base-pairing properties within RNA. It is, however, unclear whether organisms have evolved general mechanism(s) to deal with this damage. Here we show that the mRNA-surveillance pathway of no-go decay and the associated ribosome-qual...

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Detalles Bibliográficos
Autores principales: Yan, Liewei L., Simms, Carrie L., McLoughlin, Fionn, Vierstra, Richard D., Zaher, Hani S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901537/
https://www.ncbi.nlm.nih.gov/pubmed/31819057
http://dx.doi.org/10.1038/s41467-019-13579-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901537/
https://www.ncbi.nlm.nih.gov/pubmed/31819057
http://dx.doi.org/10.1038/s41467-019-13579-3

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