Bach2 deficiency leads autoreactive B cells to produce IgG autoantibodies and induce lupus through a T cell-dependent extrafollicular pathway

Class-switched IgG autoantibodies but not unswitched IgM autoantibodies play a crucial role in the development of systemic lupus erythematosus (SLE). Bach2 is known to be essential for class switch recombination of Ig genes, but recent genomic and clinical studies have suggested an association of Ba...

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Detalles Bibliográficos
Autores principales: Jang, Eunkyeong, Kim, Un Kyo, Jang, Kiseok, Song, Young Soo, Cha, Ji-Young, Yi, Hansol, Youn, Jeehee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901549/
https://www.ncbi.nlm.nih.gov/pubmed/31819031
http://dx.doi.org/10.1038/s12276-019-0352-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901549/
https://www.ncbi.nlm.nih.gov/pubmed/31819031
http://dx.doi.org/10.1038/s12276-019-0352-x

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