Defective neurogenesis and schizophrenia-like behavior in PARP-1-deficient mice

In the current study we present evidence suggesting that PARP-1 regulates neurogenesis and its deficiency may result in schizophrenia-like behavioral deficits in mice. PARP-1 knockout neural stem cells exhibited a marked upregulation of embryonic stem cell phosphatase that can suppress the prolifera...

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Detalles Bibliográficos
Autores principales: Hong, Seokheon, Yi, Jee Hyun, Lee, Soonje, Park, Chang-Hwan, Ryu, Jong Hoon, Shin, Ki Soon, Kang, Shin Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901579/
https://www.ncbi.nlm.nih.gov/pubmed/31819047
http://dx.doi.org/10.1038/s41419-019-2174-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901579/
https://www.ncbi.nlm.nih.gov/pubmed/31819047
http://dx.doi.org/10.1038/s41419-019-2174-0

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