Simvastatin Restores HDAC1/2 Activity and Improves Behavioral Deficits in Angelman Syndrome Model Mouse

Angelman syndrome (AS) is a neurodevelopmental disorder categorized by severe disability in intellectual functions and affected by the loss of function of maternally inherited UBE3A gene. Mice deficient for the maternal Ube3a recapitulates many distinguishing behavioral features of the AS and is use...

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Detalles Bibliográficos
Autores principales: Kumar, Vipendra, Joshi, Tripti, Vatsa, Naman, Singh, Brijesh Kumar, Jana, Nihar Ranjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901934/
https://www.ncbi.nlm.nih.gov/pubmed/31849603
http://dx.doi.org/10.3389/fnmol.2019.00289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901934/
https://www.ncbi.nlm.nih.gov/pubmed/31849603
http://dx.doi.org/10.3389/fnmol.2019.00289

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