c-Abl Deficiency Provides Synaptic Resiliency Against Aβ-Oligomers

Spine pathology has been implicated in the early onset of Alzheimer’s disease (AD), where Aβ-Oligomers (AβOs) cause synaptic dysfunction and loss. Previously, we described that pharmacological inhibition of c-Abl prevents AβOs-induced synaptic alterations. Hence, this kinase seems to be a key elemen...

Descripción completa

Detalles Bibliográficos
Autores principales: Gutierrez, Daniela A., Vargas, Lina M., Chandia-Cristi, América, de la Fuente, Catalina, Leal, Nancy, Alvarez, Alejandra R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902026/
https://www.ncbi.nlm.nih.gov/pubmed/31849613
http://dx.doi.org/10.3389/fncel.2019.00526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902026/
https://www.ncbi.nlm.nih.gov/pubmed/31849613
http://dx.doi.org/10.3389/fncel.2019.00526

Ejemplares similares