Enhanced Anti-melanoma Efficacy of a Pim-3-Targeting Bifunctional Small Hairpin RNA via Single-Stranded RNA-Mediated Activation of Plasmacytoid Dendritic Cells

Melanoma is the most serious type of skin cancer. The immunosuppressive tumor microenvironment and aberrant expression of some proto-oncogenes are the main cause of melanoma development. We have constructed a single-stranded RNA (ssRNA)–Pim-3–small hairpin RNA (shRNA) dual-function vector, which act...

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Detalles Bibliográficos
Autores principales: Liu, Jing, Hu, Yuan, Guo, Qie, Yu, Xin, Shao, Liwei, Zhang, Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902031/
https://www.ncbi.nlm.nih.gov/pubmed/31849942
http://dx.doi.org/10.3389/fimmu.2019.02721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902031/
https://www.ncbi.nlm.nih.gov/pubmed/31849942
http://dx.doi.org/10.3389/fimmu.2019.02721

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