Evidence for a Catalytic Strategy to Promote Nucleophile Activation in Metal-Dependent RNA-Cleaving Ribozymes and 8-17 DNAzyme

[Image: see text] An unique catalytic strategy was recently reported for the glmS ribozyme [ Bingaman et al., Nat. Chem. Biol.2017, 13, 439−44528192411] that involves promotion of productive hydrogen bonding of the O2′ nucleophile to facilitate its activation. We provide broad evidence of this strat...

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Detalles Bibliográficos
Autores principales: Ganguly, Abir, Weissman, Benjamin P., Piccirilli, Joseph A., York, Darrin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902279/
https://www.ncbi.nlm.nih.gov/pubmed/31840007
http://dx.doi.org/10.1021/acscatal.9b02035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902279/
https://www.ncbi.nlm.nih.gov/pubmed/31840007
http://dx.doi.org/10.1021/acscatal.9b02035

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