Access to a Catalytically Generated Umpolung Reagent through the Use of Cu-Catalyzed Reductive Coupling of Ketones and Allenes for the Synthesis of Chiral Vicinal Aminoalcohol Synthons

[Image: see text] We report the development of a stereoselective method for the allylation of ketones utilizing N-substituted allyl equivalents generated from a chiral allenamide. By employing N-heterocyclic carbenes as ligands for the Cu catalyst, good branched selectivity can be obtained with high...

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Detalles Bibliográficos
Autores principales: Gargaro, Samantha L., Klake, Raphael K., Burns, Kevin L., Elele, Sharon O., Gentry, Skyler L., Sieber, Joshua D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902281/
https://www.ncbi.nlm.nih.gov/pubmed/31769994
http://dx.doi.org/10.1021/acs.orglett.9b03937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902281/
https://www.ncbi.nlm.nih.gov/pubmed/31769994
http://dx.doi.org/10.1021/acs.orglett.9b03937

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