Tau- but not Aß -pathology enhances NMDAR-dependent depotentiation in AD-mouse models

Many mouse models of Alzheimer’s disease (AD) exhibit impairments in hippocampal long-term-potentiation (LTP), seemingly corroborating the strong correlation between synaptic loss and cognitive decline reported in human studies. In other AD mouse models LTP is unaffected, but other defects in synapt...

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Detalles Bibliográficos
Autores principales: Faldini, Enrico, Ahmed, Tariq, Bueé, Luc, Blum, David, Balschun, Detlef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902514/
https://www.ncbi.nlm.nih.gov/pubmed/31815648
http://dx.doi.org/10.1186/s40478-019-0813-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902514/
https://www.ncbi.nlm.nih.gov/pubmed/31815648
http://dx.doi.org/10.1186/s40478-019-0813-4

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