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Tau- but not Aß -pathology enhances NMDAR-dependent depotentiation in AD-mouse models
Many mouse models of Alzheimer’s disease (AD) exhibit impairments in hippocampal long-term-potentiation (LTP), seemingly corroborating the strong correlation between synaptic loss and cognitive decline reported in human studies. In other AD mouse models LTP is unaffected, but other defects in synapt...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902514/ https://www.ncbi.nlm.nih.gov/pubmed/31815648 http://dx.doi.org/10.1186/s40478-019-0813-4 |