HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators

HIV-1 Vif hijacks a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 enzymes and PP2A phosphatase regulators (PPP2R5A–E). APOBEC3 counteraction is essential for viral pathogenesis. However, Vif also functions through an unknown mechanism to induce G2 cell cycle arrest. Here, deep mutag...

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Detalles Bibliográficos
Autores principales: Salamango, Daniel J., Ikeda, Terumasa, Moghadasi, Seyed Arad, Wang, Jiayi, McCann, Jennifer L., Serebrenik, Artur A., Ebrahimi, Diako, Jarvis, Matthew C., Brown, William L., Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903395/
https://www.ncbi.nlm.nih.gov/pubmed/31665623
http://dx.doi.org/10.1016/j.celrep.2019.09.057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903395/
https://www.ncbi.nlm.nih.gov/pubmed/31665623
http://dx.doi.org/10.1016/j.celrep.2019.09.057

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