Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk

BACKGROUND: Muscle wasting from chronic kidney disease (CKD) or from defective insulin signalling results in morbidity and, ultimately, mortality. We have identified an endogenous mediator of insulin resistance, signal regulatory protein alpha (SIRPα), which leads to cachexia in mice and is associat...

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Detalles Bibliográficos
Autores principales: Wu, Jiao, Dong, Jiangling, Verzola, Daniela, Hruska, Keith, Garibotto, Giacomo, Hu, Zhaoyong, Mitch, William E., Thomas, Sandhya S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903446/
https://www.ncbi.nlm.nih.gov/pubmed/31507080
http://dx.doi.org/10.1002/jcsm.12459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903446/
https://www.ncbi.nlm.nih.gov/pubmed/31507080
http://dx.doi.org/10.1002/jcsm.12459

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