Replacing murine insulin 1 with human insulin protects NOD mice from diabetes

Type 1, or autoimmune, diabetes is caused by the T-cell mediated destruction of the insulin-producing pancreatic beta cells. Non-obese diabetic (NOD) mice spontaneously develop autoimmune diabetes akin to human type 1 diabetes. For this reason, the NOD mouse has been the preeminent murine model for...

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Detalles Bibliográficos
Autores principales: Elso, Colleen M., Scott, Nicholas A., Mariana, Lina, Masterman, Emma I., Sutherland, Andrew P. R., Thomas, Helen E., Mannering, Stuart I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903741/
https://www.ncbi.nlm.nih.gov/pubmed/31821343
http://dx.doi.org/10.1371/journal.pone.0225021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903741/
https://www.ncbi.nlm.nih.gov/pubmed/31821343
http://dx.doi.org/10.1371/journal.pone.0225021

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