Cargando…

Replacing murine insulin 1 with human insulin protects NOD mice from diabetes

Type 1, or autoimmune, diabetes is caused by the T-cell mediated destruction of the insulin-producing pancreatic beta cells. Non-obese diabetic (NOD) mice spontaneously develop autoimmune diabetes akin to human type 1 diabetes. For this reason, the NOD mouse has been the preeminent murine model for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elso, Colleen M., Scott, Nicholas A., Mariana, Lina, Masterman, Emma I., Sutherland, Andrew P. R., Thomas, Helen E., Mannering, Stuart I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903741/ https://www.ncbi.nlm.nih.gov/pubmed/31821343 http://dx.doi.org/10.1371/journal.pone.0225021

Ejemplares similares

Insulin expressing hepatocytes not destroyed in transgenic NOD mice
por: Tabiin, Muhammad T, et al.
Publicado: (2004)

Insulin teaches a new lesson in tolerance
por: Kay, Thomas W H, et al.
Publicado: (2009)

Identifying New Hybrid Insulin Peptides (HIPs) in Type 1 Diabetes
por: Mannering, Stuart I., et al.
Publicado: (2021)

Induced pluripotent stem cell macrophages present antigen to proinsulin-specific T cell receptors from donor-matched islet-infiltrating T cells in type 1 diabetes
por: Joshi, Kriti, et al.
Publicado: (2019)

NOD1 Activators Link Innate Immunity to Insulin Resistance
por: Schertzer, Jonathan D., et al.
Publicado: (2011)

Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice
por: Recino, Asha, et al.
Publicado: (2018)

The insulin A-chain epitope recognized by human T cells is posttranslationally modified
por: Mannering, Stuart I., et al.
Publicado: (2005)

Insulin-induced remission in new-onset NOD mice is maintained by the PD-1–PD-L1 pathway
por: Fife, Brian T., et al.
Publicado: (2006)

Do Insulin Replacement and Omega3 Protect the Male Reproductive Function of the Streptozotocin-Induced Diabetic Mice?
por: Yaghoubi, Atefe, et al.
Publicado: (2017)

Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene
Publicado: (1994)

Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice
por: Nakayama, Maki, et al.
Publicado: (2012)

Transgenic substitution with Greater Amberjack Seriola dumerili fish insulin 2 in NOD mice reduces beta cell immunogenicity
por: Foo, Kylie S., et al.
Publicado: (2019)

Use of a Hybrid Adeno-Associated Viral Vector Transposon System to Deliver the Insulin Gene to Diabetic NOD Mice
por: La, Que T., et al.
Publicado: (2020)

Insulin-Reactive T Cells Convert Diabetogenic Insulin-Reactive VH125 B Cells Into Tolerogenic Cells by Reducing Germinal Center T:B Cell Interactions in NOD Mice
por: Pearson, James A., et al.
Publicado: (2020)

Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance
por: Denou, Emmanuel, et al.
Publicado: (2015)

Sleeping Beauty Transposon Mutagenesis as a Tool for Gene Discovery in the NOD Mouse Model of Type 1 Diabetes
por: Elso, Colleen M., et al.
Publicado: (2015)

Following the Fate of One Insulin-Reactive CD4 T cell: Conversion Into Teffs and Tregs in the Periphery Controls Diabetes in NOD Mice
por: Fousteri, Georgia, et al.
Publicado: (2012)

Phenotypically distinct anti-insulin B cells repopulate pancreatic islets after anti-CD20 treatment in NOD mice
por: Boldison, Joanne, et al.
Publicado: (2019)

Preventing type 1 diabetes in late-stage pre-diabetic NOD mice with insulin: A central role for alum as adjuvant
por: Martens, Pieter-Jan, et al.
Publicado: (2022)

Silencing of NOD2 protects against diabetic cardiomyopathy in a murine diabetes model
por: Shen, Lin, et al.
Publicado: (2018)

Protection of mitochondria by intensive insulin therapy in critical illness: blood glucose control or insulin?
por: Vanhorebeek, I, et al.
Publicado: (2006)

Insulin Hypersensitivity Induced by Hepatic PTEN Gene Ablation Protects from Murine Endotoxemia
por: Guenzl, Philipp M., et al.
Publicado: (2013)

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process
Publicado: (1994)

Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity
por: Regnault, Béatrice, et al.
Publicado: (2009)

Engineering the gut for insulin replacement to treat diabetes
por: Mojibian, Majid, et al.
Publicado: (2016)

T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
por: Tran, Mai T., et al.
Publicado: (2021)

Transient B-Cell Depletion with Anti-CD20 in Combination with Proinsulin DNA Vaccine or Oral Insulin: Immunologic Effects and Efficacy in NOD Mice
por: Sarikonda, Ghanashyam, et al.
Publicado: (2013)

Pancreatic Insulin-Producing Cells Differentiated from Human Embryonic Stem Cells Correct Hyperglycemia in SCID/NOD Mice, an Animal Model of Diabetes
por: Hua, Xiu-feng, et al.
Publicado: (2014)

Syngeneically transplanted insulin producing cells differentiated from adipose derived stem cells undergo delayed damage by autoimmune responses in NOD mice
por: Tokuda, Kazunori, et al.
Publicado: (2022)

Nod2 and Nod2-regulated microbiota protect BALB/c mice from diet-induced obesity and metabolic dysfunction
por: Rodriguez-Nunez, Ivan, et al.
Publicado: (2017)

Role of insulin signaling impairment, adiponectin and dyslipidemia in peripheral and central neuropathy in mice
por: Anderson, Nicholas J., et al.
Publicado: (2014)

Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice
por: De Leon, Elizabeth R., et al.
Publicado: (2018)

Reducing endogenous insulin is linked with protection against hepatic steatosis in mice
por: Akheruzzaman, Md, et al.
Publicado: (2020)

White Adipose Tissue Resilience to Insulin Deprivation and Replacement
por: Hadji, Lilas, et al.
Publicado: (2014)

Use of cross-reactivity immunoassay to orient insulin replacement in diabetic patients with high levels of insulin antibodies
por: Cardoso Landaburu, Alejandro, et al.
Publicado: (2016)

Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes
por: Harrison, Leonard C., et al.
Publicado: (1996)

Murine Perinatal β-Cell Proliferation and the Differentiation of Human Stem Cell–Derived Insulin-Expressing Cells Require NEUROD1
por: Romer, Anthony I., et al.
Publicado: (2019)

Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells
por: Zhang, Qin, et al.
Publicado: (2019)

The Role of Lymphocyte Subsets in Accelerated Diabetes in Nonobese Diabetic–Rat Insulin Promoter–B7-1 (NOD-RIP-B7-1) Mice
por: Susan Wong, F., et al.
Publicado: (1998)

Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice
por: Sutherland, Andrew P.R., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_jmahf2iochkfi7ojle9cire0d5