Differential regulation and synthetic lethality of exclusive RB1 and CDKN2A mutations in lung cancer

Genetic alterations in lung cancer are distinctly represented in non-small cell lung carcinoma (NSCLC) and small cell lung carcinoma (SCLC). Mutation of the RB1 and CDKN2A genes, which are tightly associated with cell cycle regulation, is exclusive to SCLC and NSCLC cells, respectively. Through the...

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Detalles Bibliográficos
Autores principales: Kim, Nayoung, Song, Mee, Kim, Somin, Seo, Yujeong, Kim, Yonghwan, Yoon, Sukjoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903902/
https://www.ncbi.nlm.nih.gov/pubmed/26647789
http://dx.doi.org/10.3892/ijo.2015.3262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903902/
https://www.ncbi.nlm.nih.gov/pubmed/26647789
http://dx.doi.org/10.3892/ijo.2015.3262

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