Systematic genetic analysis of the MHC region reveals mechanistic underpinnings of HLA type associations with disease

The MHC region is highly associated with autoimmune and infectious diseases. Here we conduct an in-depth interrogation of associations between genetic variation, gene expression and disease. We create a comprehensive map of regulatory variation in the MHC region using WGS from 419 individuals to cal...

Descripción completa

Detalles Bibliográficos
Autores principales: D'Antonio, Matteo, Reyna, Joaquin, Jakubosky, David, Donovan, Margaret KR, Bonder, Marc-Jan, Matsui, Hiroko, Stegle, Oliver, Nariai, Naoki, D'Antonio-Chronowska, Agnieszka, Frazer, Kelly A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904215/
https://www.ncbi.nlm.nih.gov/pubmed/31746734
http://dx.doi.org/10.7554/eLife.48476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904215/
https://www.ncbi.nlm.nih.gov/pubmed/31746734
http://dx.doi.org/10.7554/eLife.48476

Ejemplares similares