Metformin activates KDM2A to reduce rRNA transcription and cell proliferation by dual regulation of AMPK activity and intracellular succinate level

Metformin is used to treat type 2 diabetes. Metformin activates AMP-activated kinase (AMPK), which may contribute to the action of metformin. Metformin also shows anti-proliferation activity. However, the mechanism is remained unknown. We found that treatment of MCF-7 cells with metformin induced th...

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Detalles Bibliográficos
Autores principales: Tanaka, Yuji, Konishi, Akimitsu, Obinata, Hideru, Tsuneoka, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904457/
https://www.ncbi.nlm.nih.gov/pubmed/31822720
http://dx.doi.org/10.1038/s41598-019-55075-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904457/
https://www.ncbi.nlm.nih.gov/pubmed/31822720
http://dx.doi.org/10.1038/s41598-019-55075-0

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